List of dangerous pharmaceuticals drugs

Some dangerous pharmaceuticals have been withdrawn from  the
market subsequently to their introduction due to risks for the
patients. Usually this has been due to unexpected adverse
effects that were not detected during Phase III clinical trials and
were
only apparent from post-marketing surveillance data
from the wider patient community.

* thalidomide (1950s-1960s) - withdrawn due to risk of
teratogenicity; returned to market as an anti-neoplastic
drug under FDA orphan drug rules * diethylstilbestrol
(1970s) - withdrawn due to risk of teratogenicity * phenformin
and buformin - withdrawn due to risk of lactic acidosis * ticrynafen
(1982) - ithdrawn due to risk of hepatitis*
methaqualone (1984) - withdrawn due to risk of addiction and
overdose. * triazolam (1991) - withdrawn in the United Kingdom
due to risk of psychiatric adverse drug reactions
* Fen-phen - popular combination of fenfluramine
and phentermine; phentermine remains on the
market, dexfenfluramine & fenfluramine (1997) later
withdrawn * lysergic acid diethylamide (LSD) (1950s-1960s),
marketed as a psychiatric cure-all; withdrawn after it
became widely used recreationally by hippies* terfenadine (1998)
- withdrawn due to risk of cardiac arrhythmias; superseded by
fexofenadine* mibefradil (1998) - withdrawn due to dangerous
interactions with other drugs* troglitazone (2000) - withdrawn due
to risk of hepatotoxicity; superseded by pioglitazone and
rosiglitazone* alosetron (2000) - withdrawn due to risk of fatal
complications of constipation; reintroduced 2002 on
a restricted basis * cisapride (2000s) - withdrawn in many
countries due to risk of cardiac arrhythmias
* cerivastatin (2001) - withdrawn due to risk of rhabdomyolysis
* rapacuronium (2001) - withdrawn in many countries due to risk
of fatal bronchospasm * rofecoxib (Bextra) (2004) - withdrawn due
to risk of myocardial infarction
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